Name | Amezinium mesylate |
Synonyms | Tenfortan Supratonin 30578-37-1 REGULTON (KNOLL) Amezinium mesylate RISUMIC (DAINIPPON) Amezinium Methylsulfate SUPRATONIN (GRUNENTHAL) AMEZINIUM METHYL SULFATE 4-amino-6-methoxy-1-phenyl-pyridaziniumethylsulfate 6-methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate 4-amino-6-methoxy-1-phenylpyridazin-1-ium methyl sulfate |
CAS | 30578-37-1 |
EINECS | 250-248-0 |
InChI | InChI=1/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) |
Molecular Formula | C12H15N3O5S |
Molar Mass | 313.33 |
Melting Point | 176° (dec) |
Appearance | powder to crystal |
Color | White to Light yellow |
Merck | 14,394 |
Storage Condition | Inert atmosphere,Room Temperature |
RTECS | UR6066500 |
Toxicity | LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf) |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.192 ml | 15.958 ml | 31.915 ml |
5 mM | 0.638 ml | 3.192 ml | 6.383 ml |
10 mM | 0.319 ml | 1.596 ml | 3.192 ml |
5 mM | 0.064 ml | 0.319 ml | 0.638 ml |
biological activity | Amezinium is a sympathomimetic drug that has the effect of pressurizing blood vessels in the treatment of hypotension. It is a MAO inhibitor that antagonizes the reactivity of tyramine and prevents the uptake of norepinephrine by neurons. |
Uses | A MAO inhibitor that antagonizes the reactivity of tyramine and prevents the uptake of norepinephrine by neurons. |